Catalog Number - 62308-10P

Hyper Similars C8™ Octyl is a traditional reversed-phase HPLC stationary phase developed for laboratories seeking a high-quality alternative to established C8 methods. As part of the Cogent™ Similars product line, it uses high-purity Type-B spherical silica with a bonded octyl (C8) ligand and endcapping to provide reliable chromatographic performance and excellent method reproducibility. Its surface characteristics are designed to closely match those of legacy Hypersil® and Spherisorb® C8 columns, making it particularly useful for method transfer and replacement applications.

62308-10P is a 100 mm x 4.6 mm ID analytical column packed with 3 µm, 150Å Hyper Similars C8 particles. The 100 mm length provides a balance between analysis speed and chromatographic resolution, making it well suited for routine analytical testing, quality control, and LC-MS compatible methods requiring efficient separations. The 3 µm particle size delivers greater efficiency and sharper peak shapes than comparable 5 µm columns, although higher operating backpressure should be expected. The industry-standard 4.6 mm ID format typically operates optimally at approximately 1.0–2.0 mL/min on conventional HPLC systems.

This USP L7 column is an excellent alternative for methods developed on Thermo Fisher Hypersil™ C8, Spherisorb®, and similar octyl phases. The C8 chemistry is well suited for hydrophobic and neutral compounds analyzed under reversed-phase conditions and is particularly useful when less retention is desired than with a C18 column. Common applications include long-chain fatty acids, pharmaceutical compounds, and method transfer projects requiring selectivity comparable to traditional C8 stationary phases.

Key Benefits

• Type-B spherical silica stationary phase

• Suitable alternative for USP L7 methods

• Comparable selectivity to Hypersil® and Spherisorb® C8 columns

• Balanced resolution and run time with 100 mm length

• Higher efficiency with 3 µm particles

• Reduced analysis times compared to longer columns

• Less retention than C18 columns

• End-capped octyl (C8) bonded phase

Typical Applications

• USP L7 methods

• Reversed-phase HPLC

• Pharmaceutical analysis

• Quality control testing

• Method development

• Long-chain fatty acid analysis

• Method transfer and validation

• Routine analytical separations

Specifications

• Product Type: HPLC Column

• Stationary Phase: Hyper Similars C8 Octyl

• USP Classification: L7

• Particle Size: 3 µm

• Particle Type: Type-B Spherical Silica

• Bonded Phase: C8 (Octyl)

• Endcapped: Yes

• Pore Size: 150Å

• Column Dimensions: 4.6 mm ID x 100 mm

• Length: 100 mm

• Recommended Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed for reversed-phase chromatography

• 100 mm length balances speed and resolution

• 3 µm particles provide higher efficiency and sharper peaks

• Higher backpressure than comparable 5 µm columns

• Compatible with conventional HPLC systems

• Provides less retention than comparable C18 stationary phases

• Excellent alternative for many USP L7 methods

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